Contact your care team right away if you have an erection that lasts longer than 4 hours or if it becomes painful. This may be a sign of a serious problem and must be treated right away to prevent permanent damage. If pfizer sildenafil 100 you experience symptoms of nausea, dizziness, chest pain or arm pain upon initiation of sexual activity after taking this medication, you should refrain from further activity and call your care team as soon as possible. Using this medication does not protect you or your partner against HIV or other sexually transmitted infections (STIs).
Clinical Studies
Tell your healthcare provider if you have any of the following. Heart problems, such as heart rhythm problems, chest pain, or heart failure Heart attack, stroke, or heart surgery within the past six months High blood pressure that is still too high despite taking medicines for it Peyronie's disease, or a penis with an abnormal curve or shape An erection lasting longer than four hours A blood disorder, such as sickle cell anemia An inherited eye disease called retinitis pigmentosa Vision loss, or a problem with the nerve between your eyes and brain (optic nerve) Health conditions or factors that raise the risk of optic nerve problems, such as diabetes, high cholesterol, smoking, being older than 50, or having a “crowded disc,” which is something an eye doctor may see in an eye exam Pulmonary veno-occlusive disease, a condition where blood vessels in the lungs are blocked It is not known if or how sildenafil could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take sildenafil while breastfeeding.
Dosage for pulmonary arterial hypertension (PAH)
If you take sildenafil after you eat a high-fat meal, such as a burger and fries, it may take longer to start working. Your healthcare provider may recommend limiting or avoiding grapefruit while taking sildenafil. Grapefruit or grapefruit juice can raise sildenafil levels in your body, which can increase the risk of side effects. There are no known interactions between sildenafil and alcohol. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. Side effects that you should report to your care team as soon as possible: Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision Sudden vision loss in one or both eyes Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): This list may not describe all possible side effects. Keep out of reach of children and pets.
| Parameter | Description | Typical Value |
|---|---|---|
| Absorption Rate | Time to reach peak plasma concentration | 30-120 minutes |
| Bioavailability | Percentage of dose reaching systemic circulation | 40% |
| Half-life | Time to reduce plasma concentration by half | 4 hours |
| Metabolism | Primary site of metabolism | Liver (CYP3A4 enzyme) |
| Excretion | Main routes of elimination | Feces and urine |
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 50mg | 180 + 8 Pills | 158.82€ 151.26€ | |
| Viagra Generic | 100mg | 180 + 8 Pills | 199.37€ 189.88€ | |
| Viagra Generic | 200mg | 120 + 8 Pills | 204.80€ 195.05€ | |
| Kamagra Polo | 100mg | 20 Pills | 83.56€ 79.58€ | |
| Viagra Generic | 25mg | 120 + 6 Pills | 125.56€ 119.58€ | |
| Kamagra Oral Jelly | 100mg | 90 + 8 Sachets | 303.56€ 289.10€ | |
| Kamagra Soft Tabs | 100mg | 60 + 4 Pills | 180.59€ 171.99€ | |
| Kamagra | 100mg | 180 + 6 Pills | 436.79€ 415.99€ | |
| Viagra Generic | 200mg | 30 + 2 Pills | 83.07€ 79.11€ | |
| Kamagra | 100mg | 360 + 6 Pills | 839.95€ 799.95€ | |
| Kamagra Soft Tabs | 100mg | 272 + 12 Pills | 593.42€ 565.16€ | |
| Viagra Generic | 200mg | 90 + 6 Pills | 170.79€ 162.66€ |
It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
Dosing & Uses
Do not share this medicine with others. Do not take this medication with any of the following: Nitrates, such as amyl nitrite, isosorbide sildenafil 10mg dinitrate, isosorbide mononitrate, nitroglycerin This medication may also interact with the following: Other medications may affect the way this medication works. Talk with your care team about all of the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended. This list may not describe all possible interactions. Sign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more. Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals. Sildenafil oral tablet is available as a brand-name drug and as a generic drug. Sildenafil comes in three forms: an oral tablet, an oral suspension (liquid), and an injection that’s only given by a doctor. Sildenafil oral tablet is used to treat erectile dysfunction (ED). It’s also used to treat pulmonary arterial hypertension (PAH).
4. Bottom Line
In particular, make sure that you discuss if you are using any of the following before taking sildenafil. Tell your healthcare provider about all medicines that you take or have recently taken. This may not be a complete list of medicines that can interact with sildenafil. If you or someone else has used too much sildenafil, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222. For this use, sildenafil is used only when needed.
FDA-Labeled Indications and Dosage (Adult)
Take it as your healthcare provider recommends, which is usually between 30 minutes to four hours before planned sexual activity. Do not take double or extra doses. For this use, take sildenafil as your healthcare provider recommends, which is usually three times a day. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. It comes in the form of a tablet and suspension (liquid). It also comes in an intravenous (IV) form, which is only given by a doctor. Sildenafil oral tablet is available as the brand-name drugs Viagra and Revatio. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version.
Administration and Monitoring
Ask your healthcare provider if you are unsure what to do after a missed dose. This survey is being conducted by the WebMD marketing sciences department. Sildenafil is a treatment for erectile dysfunction. It works by increasing blood flow to your penis. The brand name for this medication is Viagra®.
Dosage for ED
Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. SILDENAFIL (sil DEN a fil) treats erectile dysfunction (ED). It works by increasing blood flow to the penis, which helps to maintain an erection. In some cases, they may not be available in every strength or form as the brand-name drug. Generic oral tablets are available for both conditions, but the brand-name drugs each treat only one of the conditions. Viagra: This drug is used to treat ED.
Medical uses
Tell your care team right away if you have any change in your eyesight or hearing. This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects. With ED, you’re unable to get or maintain an erection.
- Sildenafil binds to phosphodiesterase type 5 enzymes in tissues.
- It was initially developed by Pfizer.
- The drug’s patent expired in many countries, increasing generic availability.
- It can improve quality of life for men with ED and pulmonary hypertension.
- Discuss potential interactions and health conditions with your doctor.
- Usage guidelines differ for ED and pulmonary hypertension treatment.
- Follow the prescribed dose and avoid exceeding recommended limits.
Revatio: This drug is used to treat PAH.
- Sildenafil can enhance the effects of other blood pressure medications.
- The drug’s safety profile is well-studied with many clinical trials.
- Cardiovascular health is an important consideration when taking sildenafil.
- Long-term use requires monitoring for adverse reactions.
- Patient education helps reduce risks and optimize dosage.
- Generic sildenafil offers a cost-effective alternative to branded Viagra.
- Regular health assessments can ensure safe usage.
With PAH, the blood pressure in your lungs is too high.
| Patient Group | Starting Dose | Maximum Dose | Frequency | Notes |
|---|---|---|---|---|
| Adult Men with ED | 50 mg | 100 mg | Once per day, 1 hour before sex | Adjust based on efficacy and side effects |
| Patients with Liver Impairment | 25 mg | 50 mg | Once daily | Lower doses recommended |
| Elderly Patients | 25-50 mg | 100 mg | As needed | Monitor for side effects |
Your heart has to work very hard to pump blood into your lungs.
What Is Silenafil and How Does It Work?
Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine. Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. Sildenafil belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors.
| Brand Name | Manufacturer | Formulation Type | Typical Dosage | Notes |
|---|---|---|---|---|
| Viagra | Pfizer | Tablet | 25, 50, 100 mg | Most well-known brand |
| Revatio | Pfizer | Tablet | 20 mg | For pulmonary hypertension |
| Sildenafil Citrate | Various generic manufacturers | Tablet | 25, 50, 100 mg | Generic versions available |
| Kamagra | Ajanta Pharma | Oral Gel | 100 mg | Used off-label in some countries |
A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
- Sildenafil shortens the time to achieve an erection.
- It does not cause spontaneous erections without sexual stimulation.
- Overdose signs include vision changes, persistent erections, or hypotension.
- It is linked to priapism, a sustained and painful erection.
- Always consult a healthcare provider before starting sildenafil.
- Store medication in a cool, dry place away from children.
- Combining with recreational drugs can cause dangerous interactions.
Sildenafil works in different ways, depending on the condition it’s being used to treat. For ED: Sildenafil works by increasing blood flow to the penis. This helps you get or maintain an erection. Sildenafil only works for ED if you’re sexually aroused. For PAH: Sildenafil works by relaxing the muscles and opening up the blood vessels in your lungs. This decreases the blood pressure in your lungs. Sildenafil slows down the progression of your illness. It also makes you more able to exercise. Sildenafil can be used as early as 4 hours before sex and as late as 30 minutes before sex. However, it is recommended to use this drug within an hour before sex.
1. How it works
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. They need to know if you have any of these conditions: History of blood diseases, such as sickle cell anemia or leukemia Stomach ulcers, other stomach or intestine problems An unusual or allergic reaction to sildenafil, other medications, foods, dyes, or preservatives Take this medication by mouth with a glass of water. Follow the directions on the prescription label. The dose is usually taken 1 hour before sexual activity. You should not take the dose more than once per day.
Azole Antifungals
Do not take your medication more often than directed. Talk to your care team about the use of this medication in children. This medication is not used in children for this condition. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Sildenafil should not be taken for ED more than once in a 24-hour period. But if you have certain medical conditions or are taking other drugs, your doctor may recommend that you take this drug less often than once a day. It is important to note that certain foods, particularly foods high in fat, can cause the drug to work more slowly than normal. Sildenafil oral tablet doesn’t cause drowsiness, but it can cause other side effects, including: flushing (reddening and warming of the face) an erection that lasts longer than normal If these effects are mild, they may go away within a few days or a couple of weeks.